ea0011p690 | Reproduction | ECE2006
Thompson EL
, Murphy KG
, Patterson M
, Bewick GA
, Jethwa PH
, Stamp GWH
, Todd JF
, Ghatei MA
, Bloom SR
The kisspeptins are KiSS-1 gene-derived peptides which signal through the G protein coupled receptor 54 (GPR54), and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular (ICV) or peripheral administration of kisspeptin to rodents and primates, and peripheral administration to humans, stimulates the hypothalamic-pituitary gonadal (HPG) axis. This effect is thought to be mediated via the hypothalamic gonadotrophin-releasing hormone (G...